Skip to main content


Antihistamines weaken or cancel out the effect of the body’s own neurotransmitter histamine. There are different antihistamines, each of which also docks onto other receptors in the brain. There are subdivisions into H1, H2, H3 and H4. Ideally, the doctor will help you find an antihistamine that works well and has as few or no side effects as possible.

We have compiled a list of all active ingredients for you (however, we do not claim completeness, although we always try to keep all data up to date). If you notice that an active ingredient is missing, please write to us and we will add to the list.   
f you do not respond well to an antihistamine, which can often be the case, it is worth talking to your doctor and trying other agents. Sometimes there is an antihistamine that you tolerate well or better, that is suitable for everyday use and also works well.
Another tip: Antihistamines can also have side effects. So if you get tired quickly and at the same time have to take care of small children, can no longer safely drive to work, or even if other symptoms become noticeable, you should definitely talk to your doctor and have another antihistamine prescribed.

The active ingredients according to groups

First-generation H1 receptor antagonists: 

  • Clemastine 
  • Dimetindene
  • Diphenhydramine 
  • Doxylamine 
  • Meclozine 

Second-generation H1 receptor antagonists: 

  • Azelastine 
  • Bilastine 
  • Cetirizine 
  • Desloratadine 
  • Ebastine 
  • Fexofenadine
  • Levocabastinee 
  • Levocetirizine 
  • Loratadine 
  • Terfenadine
  • Rupatadine


  • Cimetidine 
  • Famotidine 
  • Lafutidine 
  • Nizatidine 
  • Ranitidine
  • Roxatidine 

H3 und H4-Blockers:

  • Thioperamide 

As with all other medications, antihistamines have side effects, interactions and contraindications. It is always best to check with your pharmacist or doctor which antihistamine is best for you.

New Report